How Regenerative Medicine is Conquering Back Pain

February 17, 2026

Back pain is one of the most frequently reported complaints among adults, affecting nearly 70 million Americans, with 8% reporting chronic persistent pain that restricts their daily activities. Back pain accounts for over $12 billion in medical expenses per year, and adults with back pain are more likely to use medical services. Additional costs include lost work days, reduced productivity, diminished overall health, and feelings of depression and anxiety.

According to a report by GWU’s Health Policy Institute, patients who seek alternative care for back pain instead of conventional medical care report a higher level of satisfaction with their care, noting that alternative providers are more likely to explain their treatment and provide advice on self-care. Now, integrative practitioners have new regenerative tools at their fingertips that are transforming the way back pain is treated.

Learn about the types and causes of back pain, new inroads in back pain research, and how regenerative energy technologies and biologic therapies are revolutionizing back pain treatment and restoring pain-free mobility.

Types and Causes of Back Pain

Despite its widespread prevalence, only 2-4% of back pain is due to serious pathology such as cancer, infection or fracture. Over 90% is mechanical in nature, meaning it is caused by some type of motor or metabolic dysfunction that can be improved or completely corrected via conservative, non-surgical treatment.

Common types and causes of back pain include:

  • Acute mechanical non-specific back pain brought on by a one-time event such as lifting a heavy object or rotating the trunk under load. Pain can be generated from strained muscles or ligaments, facet joint strain, a torn disc, or myofascial trigger points.
  • Radicular pain involving nerve compression. This type of pain is most often caused by disc herniation that compresses the nerve root, but it can also arise from foraminal stenosis or piriformis syndrome.
  • Axial inflammatory back pain associated with systemic inflammation and arthritis.
  • Spinal stenosis pain affecting the central spinal canal, lateral recess or foramina.
  • Chronic non-specific low back pain linked to degenerative disc disease, central sensitization, facet osteoarthritis, or sacroiliac joint dysfunction.
  • Back pain related to serious pathologies like cancer, infections or fractures.
Factors that contribute to back pain include:

  • Being overweight and out of shape
  • Sedentary lifestyle with too much sitting
  • Lifestyle-related metabolic issues like chronic systemic inflammation
  • Chronic stress
  • Pregnancy
  • Degenerative bone disorders like osteoporosis, stenosis, and arthritis
  • Poor posture
  • Inefficient lifting technique
  • Repetitive overuse
  • Sacroiliac joint dysfunction
Overweight / Out of shape

Sedentary lifestyle

Metabolism & Inflammation

Chronic Stress

Pregnancy

Bone Degeneration

Poor Posture

Improper Lifting

Repetitive Strain

SI Joint Dysfunction

Back Pain’s Fascial Connection

Fascia is a universal network of connective tissue that wraps and connects tissues and structures throughout the body. Fascia coordinates with muscle to guide and control movement, distribute forces, enable gliding among various structures, and hold vital organs in place during movement. The functional role of fascia in human movement has only recently been recognized, sparking a vast body of research into its function and mechanisms.

Fascia is a collagenous tissue saturated with hyaluron – a gel-like substance that lubricates the tissue and makes it slippery, allowing for tissues and neurovascular bodies to glide smoothly without friction. Fascia is tough, smooth, and elastic, creating a state of constant elastic tension called biotensegrity that holds your body in alignment. Fascia is also densely embedded with sensory nerve endings, capable of generating more pain than muscle tissue.

When damaged, fascia becomes dense and sticky, losing its functional properties, adhering to other structures, and inhibiting gliding. Nerves can become entrapped by densified fascia, causing significant pain. Damaged fascia interferes with muscle action, impairing mobility and causing structural misalignment. It may develop myofascial trigger point – hard knots of tightly contracted fibers that cause pain and impede performance.

The thoracolumbar fascia (TLF) plays a significant role in spinal stability and mobility. The TLF helps to transmit external loads from the spine to the pelvis and lower extremities. It is densely embedded with mechanoreceptors that send important information to the brain about spinal position, allowing for corrections to optimize structural spinal support.

Recent research unveils the TLF’s critical role in chronic back pain:

  • In a 2024 cross-sectional study involving middle-aged participants with chronic low back pain (LBP), researchers set out to assess the role of the thoracolumbar fascia (TLF) and lumbar multifidus muscle in chronic LBP. Their findings revealed pronounced thickening of the thoracolumbar fascia and attenuation of the lumbar multifidus muscle compared to asymptomatic counterparts.

    The increased thickness of the TLF corresponded to greater pain intensity, while atrophy of the lumbar multifidus muscle was linked to decreased lumbar flexion. The authors concluded that treatment of chronic low back pain should target not just muscle, but fascial components as well.

  • A 2023 study used ultrasound imaging to compare thoracolumbar fascial thickness in subjects with chronic non-specific back pain vs healthy subjects. In back pain subjects, researchers found significant thickening of the TLF compared to the healthy control group. They noted that the thickened TLF caused reduced spinal adaptability and function, especially during spinal rotation.

    The research team’s conclusion suggested that TLF thickness correlates with altered fascial remodelling in chronic LBP subjects, resulting in a “frozen back”.

There are dozens more studies like these that point to fascia as a key player in chronic low back pain. Yet many medical doctors are unaware of fascia’s properties or its role in musculoskeletal dysfunction. By overlooking this important factor, patients are often subjected to treatment that merely masks symptoms, while failing to address their underlying cause.

Spinal Ligaments May Contribute to Radicular Back Pain

Radicular back pain generated from a compressed nerve root is most often caused by a herniated disc, but not always. The transforaminal ligaments are small, fibrous bands of connective tissue, commonly found in the lumbar spine, that span the intervertebral foramen – the space through which the nerve roots exit the spinal canal.

The transforaminal ligaments cross directly in front of the nerve root as it exits, and in some cases they can entrap or compress the exiting nerve, causing significant pain. Because back pain caused by ligaments is relatively rare, doctors may not even consider their contribution to back pain. Many doctors are unfamiliar with this phenomenon, but the ligaments should be considered after more common causes have been ruled out.

Diagnosing Chronic Back Pain

The causes of chronic back pain can be multifaceted, and it can be challenging to single out a specific cause based on symptoms alone. Medical doctors may refer patients for MRI if initial treatment strategies fail to alleviate pain. But MRI is costly, inconvenient, and uncomfortable for the patient, and results often come back negative, with no evidence of mechanical issues as a source of back pain.

High resolution ultrasonography provides a safe, cost-effective and convenient imaging alternative to MRI, with minimal discomfort for the patient.

Advantages of ultrasound over MRI for back pain diagnosis include:

  • Dynamic real-time imaging that allows for visualizing how various tissues and structures interact during movement.
  • Ability to visualize long bodies like nerves and muscles along their entire path.
  • Superior to MRI for visualizing soft tissues, to detect factors like nerve entrapment, SIJ dysfunction, ligament involvement, and piriformis syndrome.
  • In-clinic imaging, without MRI’s dark noisy tunnel causing claustrophobia.
  • The patient is able to move around and remain clothed during the ultrasound exam.
  • Ultrasound is safe for pregnant women and patients with pacemakers or implants.

MRI has long been considered the gold standard for spinal imaging, and it still has its place in specific circumstances, but ultrasound is gaining ground as the imaging modality of choice for back pain diagnosis.

The following table compares MRI and Ultrasound for back pain imaging:

Aspect
Ultrasound (Musculoskeletal US)
MRI (Magnetic Resonance Imaging)

Primary Use in Back Pain
Soft tissues (muscles, tendons, ligaments, facet joints, sacroiliac joints, paraspinal region), nerve entrapment (e.g., piriformis syndrome), guided injections
Gold standard for disc herniation, spinal stenosis, nerve root compression, spinal cord issues, tumors, infection, fractures, inflammatory arthritis (e.g., axial spondyloarthritis)

What it sees best
Superficial structures, dynamic/real-time movement, fluid collections, muscle tears, enthesitis, sacroiliitis (active inflammation with Doppler)
Discs, spinal cord, nerve roots, bone marrow edema, occult fractures, tumors, infection (discitis/osteomyelitis), early inflammatory changes (Modic changes, bone marrow edema)

Radiation
None
None

Cost
Low–moderate (often 10–20% of MRI cost)
High

Availability
Widely available, office-based (rheumatologists, sports med, pain physicians)
Requires dedicated MRI center, longer wait times

Exam time
10–20 minutes
30–60 minutes

Patient comfort
Very good (no claustrophobia, can be done sitting/standing, dynamic testing)
Claustrophobia common, loud, must lie still

Contraindications
Almost none
Pacemakers (non-MRI-conditional), certain implants, severe claustrophobia, 1st trimester pregnancy (relative)

Dynamic assessment
Excellent (can provoke pain with movement/probe pressure and see the exact source)
Static only

Guided injections
First-line (real-time needle visualization, very accurate)
Possible but more expensive and less practical

Sensitivity for common pathologies
  • Disc herniation/nerve root compression → Poor (cannot see into spinal canal)
  • Paraspinal muscle tear, facet effusion, SI joint inflammation → Very good
  • Early axial SpA/sacroiliitis → Comparable or superior to MRI for active inflammation (Doppler)
  • Disc herniation, stenosis, cord compression → Excellent
  • Bone marrow edema (Modic, fractures, tumor) → Excellent
  • Sacroiliitis (active) → Excellent, but US with power Doppler often sufficient and faster

Conventional vs Integrative Treatment for Persistent Back Pain

In the past, back pain was typically treated with bedrest, muscle relaxants, and anti-inflammatory drugs. In persistent cases, patients were often treated with opioids, which led to a catastrophic addiction crisis among back pain patients. But in recent years, treatment has evolved.

Today, conventional medical treatment includes patient education and encourages moderate physical activity. Physical therapy exercises and manual therapy are often recommended in the early stages, with the use of NSAIDs for pain and inflammation. However, medical doctors focus mostly on pain management, and do not consider the involvement of structures outside of the locus of pain.

By contrast, integrative practitioners consider the whole patient, not just their symptoms. Mechanical back pain often has its origins in structures outside the radius of pain, and accurate diagnosis requires an in-depth understanding of human anatomy and biomechanics. Instead of focusing on pain management, integrative clinicians pursue a holistic path to unearth the true source of pain and correct it.

Regenerative Energy and Biologic Therapies for Back Pain

Rather than relying on synthetic drugs and surgical mechanical fixes, regenerative therapists tap into the body’s innate self-healing mechanisms. Cartilagenous tissues like ligaments, tendons and fascia often have low vascularity, making them slow to heal.

Regenerative therapies give avascular tissues a boost by stimulating the body’s own immune response, to attract stem cells and growth factors to the treatment site, dramatically accelerating the healing process.

Regenerative Biologic Injections

Platelet Rich Plasma (PRP)

PRP therapy uses a sample of the patient’s own whole blood, spun in a centrifuge to extract a high concentration of platelets. When injected into damaged tissues, PRP initiates tissue repair by releasing biologically active agents. To be effective, it is critical to use the correct concentration and quality of platelets, and to and follow proper isolation techniques.

Prolotherapy

Prolotherapy uses a biologically neutral solution to irritate stubborn tissues, triggering the body’s innate healing mechanisms to grow new normal tendon, ligament and muscle fibers. Prolotherapy is often used for slow-to-heal tendon and ligament ruptures, where low vascularity inhibits tissue healing.

Hyaluronic Acid Injections

Hyaluronic acid (HA) is a natural component of joint synovial fluid and fascial tissue. When combined with myofascial release techniques, hyaluronic acid injections can help to rehydrate fascial tissue and revitalize its functional properties. HA also supports healing by replenishing joint synovial fluid.

Interfascial Plane and Nerve Hydrodissection

The hydrodissection procedure injects a saline solution into densified fascial layers under ultrasound guidance, separating the layers and releasing entrapped nerves and blood vessels. Hydrodissection is often used in conjunction with manual fascial release and hyaluronic acid injections, to fully restore fascial integrity.

Platelet Rich Plasma (PRP)
Uses a high concentration of platelets from the patient’s own blood to release biologically active agents and initiate tissue repair.

Prolotherapy
Triggers the body’s innate healing mechanisms to grow new tendon, ligament, and muscle fibers using a biologically neutral solution.

Hyaluronic Acid Injections
Rehydrates fascial tissue and replenishes joint synovial fluid to revitalize functional properties and support healing.

Interfascial Plane and Nerve Hydrodissection
Separates densified fascial layers and releases entrapped nerves and blood vessels using ultrasound-guided saline injections.

Regenerative Energy Technologies

Multimodal Extracorporeal Shockwave Therapy (ESWT)

Extracorporeal shockwave therapy (ESWT) is a noninvasive treatment that uses high-energy acoustic waves to induce biological and physiological effects. ESWT reduces pain and inflammation, helps to realign and repair collagen fibers, promotes rehydration of synovial fluid and fascial tissues, and restores friction-free knee mechanics. ESWT is most effective when guided by high-resolution ultrasound imaging.

Extracorporeal Magnetic Transduction Therapy (EMTT)

EMTT transmits high energy magnetic pulses to targeted tissues that synchronize with the body’s own magnetic fields, triggering a regenerative response. EMTT waves can penetrate deep tissues to target difficult-to-reach tendons, muscles, bones and nerves.

TECAR Therapy

TECAR, an acronym for Transfer of Energy Capacitive and Resistive, is a non-invasive therapy that uses high-frequency electrical currents to deliver radiofrequency energy via a hand-held device, creating an electromagnetic field. TECAR triggers biological responses, including enhanced blood flow and oxygenation, increased cellular metabolism, improved lymphatic drainage, reduced inflammation, and pain relief.

PENS

Percutaneous neuromodulation (PENS) is a therapeutic approach that uses electrical stimuli to calm hypersensitized nerves, a common factor in chronic back pain. PENS involves the insertion of several filament-thin needles under ultrasound guidance into muscle tissue adjacent to the targeted nerve. PENS stimulates the nerve with varying waves of low-frequency electrical current to help restore optimal neural function.

1

Extracorporeal shockwave therapy (ESWT)

2

High Energy Inductive Therapy (HEIT)

3

TECAR Therapy

4

Neuromodulation

When used in combination, energy technologies and biologic solutions have a synergistic effect:

  • ESWT + EMTT prime the microenvironment via mechanical and electromagnetic stimulation to optimize results.
  • TECAR + Laser therapy optimizes tissue metabolism, circulation, and cellular energy. Together, they extend and amplify the biological effects of PRP.
  • When used post-procedure, combined regenerative therapies dramatically reduce pain and discomfort, reinforce soft tissue healing, and promote collagen fiber realignment.

Stecco Fascial Manipulation Restores Healthy Back Function

The Stecco technique of fascial manipulation is a highly systematic approach that requires special training. When applied correctly to thickened fascial layers, Stecco not only restores elasticity and tissue gliding – it reactivates sensory receptors within the fascia, recalibrating the neuromuscular system and restoring efficient motor control.

This advanced methodology alleviates back pain, restores unrestricted movement, enhances physical performance, and optimizes whole-body mobility and stability.

This advanced methodology alleviates back pain, restores unrestricted movement, enhances physical performance, and optimizes whole-body mobility and stability. The Stecco Method was developed by Dr. Carla Stecco, the world’s leading specialist in fascial science.

Personalized Physical Therapy Restores Efficient Biomechanics

Spinal mobility and stability is fundamental to all human movement, and good spinal alignment and function rely on strong, balanced muscles and connective tissues. Once your tissues are treated and ready to bear loads, a well-designed physical therapy program can set you up for long-term spinal health.

Steer clear of PT clinics that use generic treatment protocols in a group setting, and look for a rehabilitation center that offers one-on-one customized physical therapy.

Get the Most Advanced Back Pain Treatment in NYC

New advanced therapies and technologies promise to revolutionize how back pain is diagnosed and treated, but they are rarely found under one roof, and many clinicians lack the training and expertise to effectively use them. Moreover, they do not provide stand-alone solutions, and are most effective when strategically used in combination with one another, and with manual and physical therapy.

The clinic at NYDNRehab in Midtown Manhattan is at the cutting edge of regenerative medicine, featuring a broad range of technologies and advanced therapies to effectively treat persistent back pain. Dr. Kalika’s experience and expertise is unrivaled, making NYDNRehab the clinic of choice for chronic back pain treatment in NYC.

Get Advanced Hip Flexor Rehab in NYC contact NYDNRehab today

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Verified Expert Profiles

About the Author

Dr. Lev Kalika is a world-recognized expert in musculoskeletal medicine. with 20+ years of clinical experience in diagnostic musculoskeletal ultrasonography, rehabilitative sports medicine and conservative orthopedics. In addition to operating his clinical practice in Manhattan, he regularly publishes peer-reviewed research on ultrasound-guided therapies and procedures. He serves as a peer reviewer for Springer Nature.

Dr. Kalika is an esteemed member of multiple professional organizations, including:
  • International Society for Medical Shockwave Treatment (ISMST)
  • American Institute of Ultrasound in Medicine (AIUM)
  • American Academy of Orthopedic Medicine(AAOM)
  • Fascia research Society (FRS)
  • Gait and Clinical Movement Analysis Society (GCMAS)
  • Sigma Xi, The Scientific Research Honor Society
Dr. Kalika is the only clinician in New York certified by the ISMST to perform extracorporeal shockwave therapy. He has developed his own unique approach to dynamic functional and fascial ultrasonography and has published peer-reviewed research on the topic. Dr. Kalika is a specialist in orthobiologics, a certified practitioner of Stecco Fascial Manipulation, and serves as a consultant for STT Systems – Motion Analysis & Machine Vision.
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In this instance, an athlete was originally diagnosed with minor quadriceps muscle strain and was treated for four weeks, with unsatisfactory results. When he came to our clinic, the muscle was not healing, and the patients’ muscle tissue had already begun to atrophy.

Upon examination using MSUS, we discovered that he had a full muscle thickness tear that had been overlooked by his previous provider. To mitigate damage and promote healing, surgery should have been performed immediately after the injury occurred. Because of misdiagnosis and inappropriate treatment, the patient now has permanent damage that cannot be corrected.

The most important advantage of Ultrasound over MRI imaging is its ability to zero in on the symptomatic region and obtain imaging, with active participation and feedback from the patient. Using dynamic MSUS, we can see what happens when patients contract their muscles, something that cannot be done with MRI. From a diagnostic perspective, this interaction is invaluable.

Dynamic ultrasonography examination demonstrating
the full thickness tear and already occurring muscle atrophy
due to misdiagnosis and not referring the patient
to proper diagnostic workup

Demonstration of how very small muscle defect is made and revealed
to be a complete tear with muscle contraction
under diagnostic sonography (not possible with MRI)

image

Complete tear of rectus femoris
with large hematoma (blood)

image

Separation of muscle ends due to tear elicited
on dynamic sonography examination

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